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Phospholipids enhance nucleation but not elongation of apolipoprotein C-II amyloid fibrils

Amyloid fibrils and their oligomeric intermediates accumulate in several age-related diseases where their presence is considered to play an active role in disease progression. A common characteristic of amyloid fibril formation is an initial lag phase indicative of a nucleation-elongation mechanism...

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Hlavní autoři: Ryan, Timothy M., Teoh, Chai L., Griffin, Michael D. W., Bailey, Michael F., Schuck, Peter, Howlett, Geoffrey J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887044/
https://ncbi.nlm.nih.gov/pubmed/20433849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.042
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