Effect of Apolipoprotein E on Biomarkers of Amyloid Load and Neuronal Pathology in Alzheimer Disease

OBJECTIVE: To study the effect of apolipoprotein E ε4 status on biomarkers of neurodegeneration (atrophy on magnetic resonance imaging [MRI]), neuronal injury (cerebrospinal fluid [CSF] t-tau), and brain Aβ amyloid load (CSF Aβ(1–42)) in cognitively normal subjects (CN), amnestic subjects with mild...

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Main Authors: Vemuri, Prashanthi, Wiste, Heather J., Weigand, Stephen D., Knopman, David S., Shaw, Leslie M., Trojanowski, John Q., Aisen, Paul S., Weiner, Michael, Petersen, Ronald C., Jack, Clifford R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886799/
https://ncbi.nlm.nih.gov/pubmed/20373342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21953
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