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Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice

Treating cancer patients with chemotherapeutics, such as doxorubicin (Dox), cause dilated cardiomyopathy and congestive heart failure because of oxidative stress. On the other hand, heat shock factor-1 (HSF-1), a transcription factor for heat shock proteins (Hsps), is also known to be activated in r...

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Autori principali: Vedam, Kaushik, Nishijima, Yoshinori, Druhan, Lawrence J., Khan, Mahmood, Moldovan, Nicanor I., Zweier, Jay L., Ilangovan, Govindasamy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886633/
https://ncbi.nlm.nih.gov/pubmed/20363884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01047.2009
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