Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart

Heat-shock factor 1 (HSF-1), a transcription factor for heat-shock proteins (HSPs), is known to interfere with the transcriptional activity of many oncogenic factors. In the present work, we have discovered that HSF-1 ablation induced the multidrug resistance gene, MDR1b, in the heart and increased...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Krishnamurthy, Karthikeyan, Vedam, Kaushik, Kanagasabai, Ragu, Druhan, Lawrence J., Ilangovan, Govindasamy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384141/
https://ncbi.nlm.nih.gov/pubmed/22615365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200731109
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