Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis

AIMS: Stress response, in terms of activation of stress factors, is known to cause obesity and coronary heart disease such as atherosclerosis in human. However, the underlying mechanism(s) of these pathways are not known. Here, we investigated the effect of heat shock factor-1 (HSF-1) on atheroscler...

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Publicado en:Cardiovasc Res
Autores principales: Krishnamurthy, Karthikeyan, Glaser, Shannon, Alpini, Gianfranco D., Cardounel, Arturo J., Liu, Zhenguo, Ilangovan, Govindasamy
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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ORIGINAL ARTICLES
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909164/
https://ncbi.nlm.nih.gov/pubmed/27131506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw094
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