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Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis

AIMS: Stress response, in terms of activation of stress factors, is known to cause obesity and coronary heart disease such as atherosclerosis in human. However, the underlying mechanism(s) of these pathways are not known. Here, we investigated the effect of heat shock factor-1 (HSF-1) on atheroscler...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Krishnamurthy, Karthikeyan, Glaser, Shannon, Alpini, Gianfranco D., Cardounel, Arturo J., Liu, Zhenguo, Ilangovan, Govindasamy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909164/
https://ncbi.nlm.nih.gov/pubmed/27131506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw094
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