Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis

AIMS: Stress response, in terms of activation of stress factors, is known to cause obesity and coronary heart disease such as atherosclerosis in human. However, the underlying mechanism(s) of these pathways are not known. Here, we investigated the effect of heat shock factor-1 (HSF-1) on atheroscler...

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Veröffentlicht in:Cardiovasc Res
Hauptverfasser: Krishnamurthy, Karthikeyan, Glaser, Shannon, Alpini, Gianfranco D., Cardounel, Arturo J., Liu, Zhenguo, Ilangovan, Govindasamy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909164/
https://ncbi.nlm.nih.gov/pubmed/27131506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw094
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