Defective Lamin A-Rb Signaling in Hutchinson-Gilford Progeria Syndrome and Reversal by Farnesyltransferase Inhibition

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by a de novo heterozygous point mutation G608G (GGC>GGT) within exon 11 of LMNA gene encoding A-type nuclear lamins. This mutation elicits an internal deletion of 50 amino acids in the carboxyl-terminus of prela...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Marji, Jackleen, O'Donoghue, Seán I., McClintock, Dayle, Satagopam, Venkata P., Schneider, Reinhard, Ratner, Desiree, J. Worman, Howard, Gordon, Leslie B., Djabali, Karima
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886113/
https://ncbi.nlm.nih.gov/pubmed/20559568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011132
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars