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Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site
Type IB DNA topoisomerases (TopIB) are enzymes that relax supercoils by cleaving and resealing one strand of duplex DNA within a protein clamp that embraces a DNA segment. A longstanding conundrum concerns the capacity of TopIB enzymes to stabilize intramolecular duplex DNA crossovers and, in the ca...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2886027/ https://ncbi.nlm.nih.gov/pubmed/20541510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.03.007 |
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