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Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site

Type IB DNA topoisomerases (TopIB) are enzymes that relax supercoils by cleaving and resealing one strand of duplex DNA within a protein clamp that embraces a DNA segment. A longstanding conundrum concerns the capacity of TopIB enzymes to stabilize intramolecular duplex DNA crossovers and, in the ca...

詳細記述

保存先:
書誌詳細
主要な著者: Patel, Asmita, Yakovleva, Lyudmila, Shuman, Stewart, Mondragón, Alfonso
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886027/
https://ncbi.nlm.nih.gov/pubmed/20541510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.03.007
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