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Chemical and Traditional Mutagenesis of Vaccinia DNA Topoisomerase Provides Insights to Cleavage Site Recognition and Transesterification Chemistry
Vaccinia DNA topoisomerase IB (TopIB) relaxes supercoils by forming and resealing a covalent DNA-(3′-phosphotyrosyl)-enzyme intermediate. Here we gained new insights to the TopIB mechanism through “chemical mutagenesis.” Meta-substituted analogs of Tyr(274) were introduced by in vitro translation in...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2414267/ https://ncbi.nlm.nih.gov/pubmed/18367446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801595200 |
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