Towards an understanding of the mechanism of action of praziquantel

Although praziquantel (PZQ) has been used to treat schistosomiasis for over 20 years its mechanism of action remains unknown. We have developed an assay based on the transcriptional response of Schistosoma mansoni PR-1 to heat shock to confirm that while 6-week post-infection (p.i.) schistosomes are...

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Detalhes bibliográficos
Main Authors: Aragon, Anthony D., Imani, Reza A., Blackburn, Vint R., Cupit, Pauline M., Melman, Sandra D., Goronga, Tinopiwa, Webb, Thomas, Loker, Eric S., Cunningham, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886009/
https://ncbi.nlm.nih.gov/pubmed/19100294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2008.11.007
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