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Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel

Schistosomiasis is a highly prevalent neglected tropical disease caused by blood-dwelling helminths of the genus Schistosoma. Praziquantel (PZQ) is the only drug available widely for the treatment of this disease and is administered in racemic form, even though only the (R)-isomer has significant an...

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Main Authors: Sharma, Lalit Kumar, Cupit, Pauline M., Goronga, Tino, Webb, Thomas R., Cunningham, Charles
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055354/
https://ncbi.nlm.nih.gov/pubmed/24775301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.04.014
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