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Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

Defects in ribosome biogenesis and function are present in a growing list of human syndromes associated with cancer susceptibility. One example is X-linked dyskeratosis congenita (X-DC) in which the DKC1 gene, encoding for an enzyme that modifies ribosomal RNA, is found to be mutated. How ribosome d...

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Main Authors: Bellodi, Cristian, Kopmar, Noam, Ruggero, Davide
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885924/
https://ncbi.nlm.nih.gov/pubmed/20453831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.83
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