Loss of CNGB1 Protein Leads to Olfactory Dysfunction and Subciliary Cyclic Nucleotide-gated Channel Trapping

Olfactory receptor neurons (ORNs) employ a cyclic nucleotide-gated (CNG) channel to generate a receptor current in response to an odorant-induced rise in cAMP. This channel contains three types of subunits, the principal CNGA2 subunit and two modulatory subunits (CNGA4 and CNGB1b). Here, we have ana...

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Hauptverfasser: Michalakis, Stylianos, Reisert, Johannes, Geiger, Heidi, Wetzel, Christian, Zong, Xiangang, Bradley, Jonathan, Spehr, Marc, Hüttl, Sabine, Gerstner, Andrea, Pfeifer, Alexander, Hatt, Hanns, Yau, King-Wai, Biel, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885922/
https://ncbi.nlm.nih.gov/pubmed/16980309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M606409200
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