The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance

The Myc protein suppresses the transcription of several cyclin-dependent kinase inhibitors (CKIs) via binding to Miz1; whether this interaction is important for Myc's ability to induce or maintain tumorigenesis is not known. Here we show that the oncogenic potential of a point mutant of Myc (My...

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Autores principales: van Riggelen, Jan, Müller, Judith, Otto, Tobias, Beuger, Vincent, Yetil, Alper, Choi, Peter S., Kosan, Christian, Möröy, Tarik, Felsher, Dean W., Eilers, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2010
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885663/
https://ncbi.nlm.nih.gov/pubmed/20551174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.585710
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