Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor

The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies...

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Detalhes bibliográficos
Main Authors: Scherzer-Attali, Roni, Pellarin, Riccardo, Convertino, Marino, Frydman-Marom, Anat, Egoz-Matia, Nirit, Peled, Sivan, Levy-Sakin, Michal, Shalev, Deborah E., Caflisch, Amedeo, Gazit, Ehud, Segal, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885425/
https://ncbi.nlm.nih.gov/pubmed/20559435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011101
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