Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies

The intracellular oligomerization of α-synuclein is associated with Parkinson's disease and appears to be an important target for disease-modifying treatment. Yet, to date, there is no specific inhibitor for this aggregation process. Using unbiased systematic peptide array analysis, we indentif...

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Detalhes bibliográficos
Main Authors: Shaltiel-Karyo, Ronit, Frenkel-Pinter, Moran, Egoz-Matia, Nirit, Frydman-Marom, Anat, Shalev, Deborah E., Segal, Daniel, Gazit, Ehud
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978097/
https://ncbi.nlm.nih.gov/pubmed/21085664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013863
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