Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrP(C) on Neuronal Cells and PrP(RES) in Infected Cell Cultures

BACKGROUND: Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrP(C) expression and subsequent prion neuropathology, exploiting the phenomenon that disease severity and progression correlate with host PrP(C) expression levels. However, delivery of len...

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Bibliografische gegevens
Hoofdauteurs: Pulford, Bruce, Reim, Natalia, Bell, Aimee, Veatch, Jessica, Forster, Genevieve, Bender, Heather, Meyerett, Crystal, Hafeman, Scott, Michel, Brady, Johnson, Theodore, Wyckoff, A. Christy, Miele, Gino, Julius, Christian, Kranich, Jan, Schenkel, Alan, Dow, Steven, Zabel, Mark D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2010
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885418/
https://ncbi.nlm.nih.gov/pubmed/20559428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011085
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