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In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate

Protein misfolding cyclic amplification (PMCA) is an in vitro simulation of prion replication, which relies on the use of normal brain homogenate derived from host species as substrate for the specific amplification of abnormal prion protein, PrP(Sc). Studies showed that recombinant cellular PrP, Pr...

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Bibliografski detalji
Izdano u:Prion
Glavni autori: Faburay, Bonto, Tark, Dongseob, Kanthasamy, Anumantha G, Richt, Juergen A
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601224/
https://ncbi.nlm.nih.gov/pubmed/25495764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336896.2014.983753
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