In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate

Protein misfolding cyclic amplification (PMCA) is an in vitro simulation of prion replication, which relies on the use of normal brain homogenate derived from host species as substrate for the specific amplification of abnormal prion protein, PrP(Sc). Studies showed that recombinant cellular PrP, Pr...

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Bibliographic Details
Published in:Prion
Main Authors: Faburay, Bonto, Tark, Dongseob, Kanthasamy, Anumantha G, Richt, Juergen A
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601224/
https://ncbi.nlm.nih.gov/pubmed/25495764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336896.2014.983753
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