Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model.

Current organ preservation strategies subject graft vasculature to severe hypoxia (PO2 approximately 20 Torr), potentially compromising vascular function and limiting successful transplantation. Previous work has shown that cAMP modulates endothelial cell (EC) antithrombogenicity, barrier function,...

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Foilsithe in:J Clin Invest
Main Authors: Pinsky, D, Oz, M, Liao, H, Morris, S, Brett, J, Sciacca, R, Karakurum, M, Van Lookeren Campagne, M, Platt, J, Nowygrod, R
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 1993
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288503/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8254053/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116922
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