Hypoxia modulates EWS-FLI1 transcriptional signature and enhances malignant properties of Ewing's sarcoma cells in-vitro

Hypoxia is an important condition in the tumor cell microenvironment and approximately 1-1.5% of the genome is transcriptionally responsive to hypoxia with hypoxia-inducible factor-1 (HIF-1) as a major mediator of transcriptional activation. Tumor hypoxia is associated with a more aggressive phenoty...

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Hoofdauteurs: Aryee, Dave N.T., Niedan, Stephan, Kauer, Maximilian, Schwentner, Raphaela, Bennani-Baiti, Idriss M., Ban, Jozef, Muehlbacher, Karin, Kreppel, Michael, Walker, Robert L., Meltzer, Paul, Poremba, Christopher, Kofler, Reinhard, Kovar, Heinrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884367/
https://ncbi.nlm.nih.gov/pubmed/20442286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4333
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