Increased cyclic guanosine monophosphate production and overexpression of atrial natriuretic peptide A-receptor mRNA in spontaneously hypertensive rats.

Atrial natriuretic peptide (ANP) specifically stimulates particulate guanylate cyclase, and cyclic guanosine monophosphate (cGMP) has been recognized as its second messenger. Spontaneously hypertensive rats (SHR) have elevated plasma ANP levels, but manifest an exaggerated natriuretic and diuretic r...

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Main Authors: Tremblay, J, Huot, C, Willenbrock, R C, Bayard, F, Gossard, F, Fujio, N, Koch, C, Kuchel, O, Debinski, W, Hamet, P
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC288435/
https://ncbi.nlm.nih.gov/pubmed/7901238
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