Increased cyclic guanosine monophosphate production and overexpression of atrial natriuretic peptide A-receptor mRNA in spontaneously hypertensive rats.

Atrial natriuretic peptide (ANP) specifically stimulates particulate guanylate cyclase, and cyclic guanosine monophosphate (cGMP) has been recognized as its second messenger. Spontaneously hypertensive rats (SHR) have elevated plasma ANP levels, but manifest an exaggerated natriuretic and diuretic r...

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Publicado en:J Clin Invest
Autores principales: Tremblay, J, Huot, C, Willenbrock, R C, Bayard, F, Gossard, F, Fujio, N, Koch, C, Kuchel, O, Debinski, W, Hamet, P
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288435/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7901238/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116858
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