Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double strand break repair

As single agents, chemical inhibitors of poly(ADP-ribose) polymerase (PARP) are non-toxic and have clinical efficacy against BRCA1 and BRCA2 deficient tumours. PARP inhibitors also enhance the cytotoxicity of ionizing radiation (IR) and alkylating agents, but will only improve clinical outcomes if t...

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Bibliographic Details
Main Authors: Löser, Dana A., Shibata, Atsushi, Shibata, Akiko K., Woodbine, Lisa J., Jeggo, Penny A., Chalmers, Anthony J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884153/
https://ncbi.nlm.nih.gov/pubmed/20530711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1027
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