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Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double strand break repair
As single agents, chemical inhibitors of poly(ADP-ribose) polymerase (PARP) are non-toxic and have clinical efficacy against BRCA1 and BRCA2 deficient tumours. PARP inhibitors also enhance the cytotoxicity of ionizing radiation (IR) and alkylating agents, but will only improve clinical outcomes if t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2884153/ https://ncbi.nlm.nih.gov/pubmed/20530711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1027 |
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