Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation inducing stimulus

The cytosine analogue decitabine alters hematopoietic differentiation. For example, decitabine treatment increases self-renewal of normal hematopoietic stem cells. The mechanisms underlying decitabine induced shifts in differentiation are poorly understood, but likely relate to the ability of decita...

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Main Authors: Hu, Zhenbo, Negrotto, Soledad, Gu, Xiaorong, Mahfouz, Reda, Ng, Kwok Peng, Ebrahem, Quteba, Copelan, Edward, Singh, Harinder, Maciejewski, Jaroslaw P, Saunthararajah, Yogen
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884053/
https://ncbi.nlm.nih.gov/pubmed/20501800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0191
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