Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model

BACKGROUND: There is strong evidence demonstrating that activation of epidermal growth factor receptors (EGFRs) leads to tumor growth, progression, invasion and metastasis. Erlotinib and gefitinib, two EGFR-targeted agents, have been shown to be relevant drugs for lung cancer treatment. Recent studi...

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Bibliografiska uppgifter
Huvudupphovsmän: Diaz, Roque, Nguewa, Paul A, Parrondo, Ricardo, Perez-Stable, Carlos, Manrique, Irene, Redrado, Miriam, Catena, Raul, Collantes, Maria, Peñuelas, Ivan, Díaz-González, Juan Antonio, Calvo, Alfonso
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883966/
https://ncbi.nlm.nih.gov/pubmed/20459769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-188
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