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The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models

As key molecules which drive progression and chemoresistance in gastrointestinal cancers, EGFR and HER2 have become efficacious drug targets in this setting. Lapatinib is an EGFR/HER2 kinase inhibitor suppressing signaling through the RAS/RAF/MEK/MAPK and PI3K/AKT pathways. Histone deacetylase inhib...

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書誌詳細
主要な著者: LaBonte, Melissa J., Wilson, Peter M., Fazzone, Will, Russell, Jared, Louie, Stan G., El-Khoueiry, Anthony, Lenz, Heinz-Josef, Ladner, Robert D.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118510/
https://ncbi.nlm.nih.gov/pubmed/21464044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2430
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