The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer

BACKGROUND: Lapatinib plus capecitabine emerged as an efficacious therapy in metastatic breast cancer (mBC). We aimed to identify germline single-nucleotide polymorphisms (SNPs) in genes involved in capecitabine catabolism and human epidermal receptor signaling that were associated with clinical out...

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Autori principali: LaBonte, M. J., Wilson, P. M., Yang, D., Zhang, W., Ladner, R. D., Ning, Y., Gerger, A., Bohanes, P. O., Benhaim, L., El-khoueiry, R., El-khoueiry, A., Lenz, H.-J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360546/
https://ncbi.nlm.nih.gov/pubmed/21989330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdr445
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