Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2

BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has been shown to exert a synergistic antitumor effect when combined with fluoropyrimidine. This synergy may be attributable to the downregulation of thymidylate synthase (TS), which is frequently overexpressed in fluo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kim, Hwang-Phill, Yoon, Young-Kwang, Kim, Jin-Won, Han, Sae-Won, Hur, Hyung-Seok, Park, Jinah, Lee, Ju-Hee, Oh, Do-Youn, Im, Seock-Ah, Bang, Yung-Jue, Kim, Tae-You
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691960/
https://ncbi.nlm.nih.gov/pubmed/19529774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005933
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados