Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2

BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has been shown to exert a synergistic antitumor effect when combined with fluoropyrimidine. This synergy may be attributable to the downregulation of thymidylate synthase (TS), which is frequently overexpressed in fluo...

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Main Authors: Kim, Hwang-Phill, Yoon, Young-Kwang, Kim, Jin-Won, Han, Sae-Won, Hur, Hyung-Seok, Park, Jinah, Lee, Ju-Hee, Oh, Do-Youn, Im, Seock-Ah, Bang, Yung-Jue, Kim, Tae-You
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691960/
https://ncbi.nlm.nih.gov/pubmed/19529774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005933
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