The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells

Overexpression of cyclooxygenase-2 (COX-2) and elevated levels of its enzymatic product prostaglandin E2 (PGE(2)) occur in the majority of colorectal cancers and play important roles in colorectal tumorigenesis. However, despite the established prosurvival role of PGE(2) in cancer, the underlying me...

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Main Authors: Greenhough, Alexander, Wallam, Catherine A., Hicks, Diane J., Moorghen, Moganaden, Williams, Ann C., Paraskeva, Chris
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883743/
https://ncbi.nlm.nih.gov/pubmed/20348947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.94
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