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Tumor Necrosis Factor-α Promotes Myocarditis in Female Mice Infected with Coxsackievirus B3 Through Upregulation of CD1d on Hematopoietic Cells

Coxsackievirus B3 (CVB3) induces cardiac inflammation (myocarditis) in male but not female C57BL/6 mice. Protection of females correlates with reduced expression of TNF-α and IL-1β at both the mRNA and protein levels in the heart. Treatment of females with 300 ng/mouse of recombinant TNF-α on days +...

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Bibliografiske detaljer
Hovedforfatter: Huber, Sally
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883509/
https://ncbi.nlm.nih.gov/pubmed/20121405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2009.0063
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