Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

Transgenic mice were prepared that expressed a dysfunctional apo E variant, apo E (Arg-112, Cys-142), which is associated with dominant inheritance of type III hyperlipoproteinemia (type III HLP) in humans. Among eight founder mice, plasma apo E (Arg-112, Cys-142) levels varied 100-fold and directly...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Fazio, S, Lee, Y L, Ji, Z S, Rall, S C
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288296/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376602/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116728
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