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Interaction of Native Bile Acids with Human Apical Sodium Dependent Bile Acid Transporter (hASBT): Influence of Steroidal Hydroxylation Pattern and C-24 Conjugation

PURPOSE: The human Apical Sodium-dependent Bile Acid Transporter (hASBT) is a potential target for drug delivery, but an understanding of hASBT substrate requirements is lacking. The objective of this study was to characterize hASBT interaction with its native substrates, bile acids, including an ev...

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Main Authors: Balakrishnan, Anand, Wring, Steven A., Polli, James E.
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882938/
https://ncbi.nlm.nih.gov/pubmed/16783481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-006-0219-4
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