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Differentiation of Kappa Opioid Agonist-Induced Antinociception by Naltrexone Apparent pA(2) Analysis in Rhesus Monkeys,

Naltrexone (NTX) exhibited approximately 3-fold higher affinity for sites labeled by [(3)H]U69,593 (putative κ(1)-selective ligand) than [(3)H]bremazocine (non-selective ligand) in the presence of mu and delta receptor blockade in monkey brain membranes. This led us to test an hypothesis that NTX co...

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Autori principali: Ko, Mei-Chuan, Butelman, Eduardo R., Traynor, John R., Woods, James H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882849/
https://ncbi.nlm.nih.gov/pubmed/9580592
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