BCL6 is critical for the development of a diverse primary B cell repertoire

BCL6 protects germinal center (GC) B cells against DNA damage–induced apoptosis during somatic hypermutation and class-switch recombination. Although expression of BCL6 was not found in early IL-7–dependent B cell precursors, we report that IL-7Rα–Stat5 signaling negatively regulates BCL6. Upon prod...

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Hauptverfasser: Duy, Cihangir, Yu, J. Jessica, Nahar, Rahul, Swaminathan, Srividya, Kweon, Soo-Mi, Polo, Jose M., Valls, Ester, Klemm, Lars, Shojaee, Seyedmehdi, Cerchietti, Leandro, Schuh, Wolfgang, Jäck, Hans-Martin, Hurtz, Christian, Ramezani-Rad, Parham, Herzog, Sebastian, Jumaa, Hassan, Koeffler, H. Phillip, de Alborán, Ignacio Moreno, Melnick, Ari M., Ye, B. Hilda, Müschen, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882829/
https://ncbi.nlm.nih.gov/pubmed/20498019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091299
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