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Manipulation of Thiocillin Variants by Prepeptide Gene Replacement: Structure, Conformation, and Activity of Heterocycle Substitution Mutants
Bacillus cereus ATCC 14579 converts the C-terminal 14 residues of a 52-mer prepeptide into a related set of eight variants of the thiocillin subclass of thiazolyl peptide antibiotics by a cascade of posttranslational modifications that alter 13 of those 14 residues. We have introduced prepeptide gen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882596/ https://ncbi.nlm.nih.gov/pubmed/20455532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102339q |
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