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Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin
The thiazolylpeptides are a family of >50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis. Here, we report a biosynthetic gene cluster for thiocillin and establish that it, and by extension the whole class, is ribosomally synthesized. Remarkably, the C-termina...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650375/ https://ncbi.nlm.nih.gov/pubmed/19196969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900008106 |
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