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Thiazolyl Peptide Antibiotic Biosynthesis: A Cascade of Post-translational Modifications on Ribosomal Nascent Proteins

Antibiotics of the thiocillin, GE2270A, and thiostrepton class, which block steps in bacterial protein synthesis, contain a trithiazolyl (tetrahydro)pyridine core that provides the architectural constraints for high affinity binding to either the 50 S ribosomal subunit or elongation factor Tu. These...

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Bibliografiske detaljer
Main Authors: Walsh, Christopher T., Acker, Michael G., Bowers, Albert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934618/
https://ncbi.nlm.nih.gov/pubmed/20522549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R110.135970
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