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Manipulation of Thiocillin Variants by Prepeptide Gene Replacement: Structure, Conformation, and Activity of Heterocycle Substitution Mutants

Bacillus cereus ATCC 14579 converts the C-terminal 14 residues of a 52-mer prepeptide into a related set of eight variants of the thiocillin subclass of thiazolyl peptide antibiotics by a cascade of posttranslational modifications that alter 13 of those 14 residues. We have introduced prepeptide gen...

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Bibliografiske detaljer
Main Authors: Bowers, Albert A., Acker, Michael G., Koglin, Alexander, Walsh, Christopher T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882596/
https://ncbi.nlm.nih.gov/pubmed/20455532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102339q
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