Dendritic cell directed CTLA-4 engagement during pancreatic β-cell antigen presentation delays type 1 diabetes

The levels of expression of alternatively spliced variants of CTLA-4 and insufficient CTLA-4 signaling have been implicated in type 1 diabetes (T1D). Hence, we hypothesized that increasing CTLA-4 specific ligand strength on autoantigen presenting dendritic cells (DCs) can enhance ligation of CTLA-4...

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Hlavní autoři: Karumuthil-Melethil, Subha, Perez, Nicolas, Li, Ruobing, Prabhakar, Bellur S., Holterman, Mark J., Vasu, Chenthamarakshan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882504/
https://ncbi.nlm.nih.gov/pubmed/20483724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903130
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