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Dendritic cell directed CTLA-4 engagement during pancreatic β-cell antigen presentation delays type 1 diabetes
The levels of expression of alternatively spliced variants of CTLA-4 and insufficient CTLA-4 signaling have been implicated in type 1 diabetes (T1D). Hence, we hypothesized that increasing CTLA-4 specific ligand strength on autoantigen presenting dendritic cells (DCs) can enhance ligation of CTLA-4...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882504/ https://ncbi.nlm.nih.gov/pubmed/20483724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903130 |
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