Modulation of Dendritic Cells Using Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Delays type 1 diabetes by Enhancing CD4+CD25+ Regulatory T Cell Function

Abnormalities in DC function are implicated in defective immune regulation that leads to type-1 diabetes (T1D) in NOD mice and humans. In this study, we used GM-CSF and Flt3-L to modulate DC function in NOD mice and observed the effects on T1D development. Treatment with either ligand at earlier sta...

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Bibliographic Details
Main Authors: Cheatem, Donald, Ganesh, Balaji B., Gangi, Eryn, Vasu, Chenthamarakshan, Prabhakar, Bellur S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701651/
https://ncbi.nlm.nih.gov/pubmed/19171501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2008.12.001
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