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Preferential co-stimulation by CD80 results in IL-10 dependent TGF-β1+ adaptive regulatory T cell generation
Costimulatory ligands, CD80 and CD86 have different binding preferences and affinities to their receptors CD28 and CTLA-4. Earlier, we demonstrated that CD80 binds to CTLA-4 with higher affinity and has a role in suppressing T cell response. The current study demonstrates that blockade of CD86 upon...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435403/ https://ncbi.nlm.nih.gov/pubmed/18453575 |
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