Preferential co-stimulation by CD80 results in IL-10 dependent TGF-β1+ adaptive regulatory T cell generation

Costimulatory ligands, CD80 and CD86 have different binding preferences and affinities to their receptors CD28 and CTLA-4. Earlier, we demonstrated that CD80 binds to CTLA-4 with higher affinity and has a role in suppressing T cell response. The current study demonstrates that blockade of CD86 upon...

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Huvudupphovsmän: Perez, Nicolas, Karumuthil-Melethil, Subha, Li, Ruobing, Prabhakar, Bellur S., Holterman, Mark J., Vasu, Chenthamarakshan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435403/
https://ncbi.nlm.nih.gov/pubmed/18453575
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