H3K27 Trimethylation Is an Early Epigenetic Event of p16(INK4a) Silencing for Regaining Tumorigenesis in Fusion Reprogrammed Hepatoma Cells

Stable epigenetic silencing of p16(INK4a) is a common event in hepatocellular carcinoma (HCC) cells, which is associated with abnormal cell proliferation and liberation from cell cycle arrest. Understanding the early epigenetic events in silencing p16(INK4a) expression may illuminate a prognostic st...

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Hlavní autoři: Yao, Jia-Yi, Zhang, Lei, Zhang, Xin, He, Zhi-Ying, Ma, Yue, Hui, Li-Jian, Wang, Xin, Hu, Yi-Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881805/
https://ncbi.nlm.nih.gov/pubmed/20382980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077974
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