Nalaganje...
Epigenetic Silencing of the p16(INK4a) Tumor Suppressor is Associated with Loss of CTCF Binding and a Chromatin Boundary
The p16(INK4a) tumor suppressor gene is a frequent target of epigenetic inactivation in human cancers, which is considered to be an early event in breast carcinogenesis. Here we describe the existence of a chromatin boundary upstream of the p16 gene that is lost when this gene is aberrantly silenced...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2723750/ https://ncbi.nlm.nih.gov/pubmed/19450526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.001 |
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