A Novel Entamoeba histolytica Cysteine Proteinase, EhCP4, Is Key for Invasive Amebiasis and a Therapeutic Target

Entamoeba histolytica cysteine proteinases (EhCPs) play a key role in disrupting the colonic epithelial barrier and the innate host immune response during invasion of E. histolytica, the protozoan cause of human amebiasis. EhCPs are encoded by 50 genes, of which ehcp4 (ehcp-a4) is the most up-regula...

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Main Authors: He, Chen, Nora, George P., Schneider, Eric L., Kerr, Iain D., Hansell, Elizabeth, Hirata, Ken, Gonzalez, David, Sajid, Mohammed, Boyd, Sarah E., Hruz, Petr, Cobo, Eduardo R., Le, Christine, Liu, Wei-ting, Eckmann, Lars, Dorrestein, Pieter C., Houpt, Eric R., Brinen, Linda S., Craik, Charles S., Roush, William R., McKerrow, James, Reed, Sharon L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881777/
https://ncbi.nlm.nih.gov/pubmed/20378535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086181
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