Use of Recombinant Entamoeba histolytica Cysteine Proteinase 1 To Identify a Potent Inhibitor of Amebic Invasion in a Human Colonic Model

Cysteine proteinases are key virulence factors of the protozoan parasite Entamoeba histolytica. We have shown that cysteine proteinases play a central role in tissue invasion and disruption of host defenses by digesting components of the extracellular matrix, immunoglobulins, complement, and cytokin...

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Autori principali: Meléndez-López, Samuel G., Herdman, Scott, Hirata, Ken, Choi, Min-Ho, Choe, Youngchool, Craik, Charles, Caffrey, Conor R., Hansell, Elisabeth, Chávez-Munguía, Bibiana, Chen, Yen Ting, Roush, William R., McKerrow, James, Eckmann, Lars, Guo, Jianhua, Stanley, Samuel L., Reed, Sharon L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951106/
https://ncbi.nlm.nih.gov/pubmed/17513563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00094-07
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