A Novel Entamoeba histolytica Cysteine Proteinase, EhCP4, Is Key for Invasive Amebiasis and a Therapeutic Target

Entamoeba histolytica cysteine proteinases (EhCPs) play a key role in disrupting the colonic epithelial barrier and the innate host immune response during invasion of E. histolytica, the protozoan cause of human amebiasis. EhCPs are encoded by 50 genes, of which ehcp4 (ehcp-a4) is the most up-regula...

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Detalhes bibliográficos
Main Authors: He, Chen, Nora, George P., Schneider, Eric L., Kerr, Iain D., Hansell, Elizabeth, Hirata, Ken, Gonzalez, David, Sajid, Mohammed, Boyd, Sarah E., Hruz, Petr, Cobo, Eduardo R., Le, Christine, Liu, Wei-ting, Eckmann, Lars, Dorrestein, Pieter C., Houpt, Eric R., Brinen, Linda S., Craik, Charles S., Roush, William R., McKerrow, James, Reed, Sharon L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881777/
https://ncbi.nlm.nih.gov/pubmed/20378535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086181
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