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MDM2 Promotes Proteasomal Degradation of p21(Waf1) via a Conformation Change
MDM2 plays a major role in cancer development and progression via both p53-dependent and -independent functions. One of its p53-independent functions is the induction of the ubiquitin-independent proteasomal degradation of p21(Waf1). The present study was designed to characterize the mechanism(s) by...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881766/ https://ncbi.nlm.nih.gov/pubmed/20308078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059568 |
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